This is the rarest hair and eye color combination

blue eyes with red hair

Often there's no known reason for it, but it can be caused by a condition known as piebaldism, a lack of pigment-producing cells in patches of hair, skin, and, in some cases, one eye. New classifications have determined that gray is its own standard color. (It was previously, and incorrectly, lumped in with blue.) With this change, gray now tops the list as the rarest eye color. While some eyes may look black, they're either just a very dark brown or large pupils. Have you ever wondered if people with blue eyes are related? It acts as a receptor or ‘receiver’ for pigment-driving hormones as well as the pain-relieving hormones known as endorphins.

Genetics behind red hair and green eyes together

However, further research is necessary because this study was limited by the lack of redheads — even in their 3,500-plus subject pool. Experts estimate that somewhere betwen 1-2% of the world’s population has red hair. The vast majority of people with red hair have a mutation in the MC1R gene, which is responsible for coding the melanocortin-1 receptor. This protein plays a role in the production of melanin, which gives skin and hair its color. People with red hair typically have less melanin in their skin, which makes them more susceptible to sunburn and skin cancer. The color of the eyes is a physical trait of humans that is determined by more than one gene.

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blue eyes with red hair

The likelihood of this happening is quite rare, especially if neither of your parents has red hair or blue eyes. Sometimes, however, the genetic stars align, and individuals are born with the rare combination of red hair and blue eyes. According to Medical Daily, blue-eyed redheads take the prize for rarest hair and eye color combination. Both genes for blue eyes and red hair are recessive, so if you can remember back to high school biology and Punnett Squares, you’ll know just how rare this combo is. Approximately 0.17 percent of the world’s population has red hair and blue eyes.

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Why is it so rare?

And we know your husband has at least one B since he has brown eyes. Brown is dominant over blue which means if either or both of your copies of this gene are B, then you have brown eyes (remember, we have two copies of most of our genes — one from mom and one from dad). People in countries farther away from the equator tend to have lighter-colored eyes and skin. Darker eyes and skin are common in warmer locales, closer to the equator. We can more easily spot a redhead in a crowd than a blonde or brunette. They are few and far between; about one to two percent of the population possesses natural red locks.

A specific mutation in the HERC2 gene along with single nucleotide polymorphisms (SNPs) in the OCA2 gene causes the development of a spectrum of different eye colors in humans. The condition of heterochromia, where the two eyes have different coloration, is also due to the interaction of the OCA2 and HERC2 genes. In addition, with both red hair and blue eyes being something akin to recessive traits, having parents who are able to pass on two sets of recessive genes is very unlikely. In most cases, you’d have blue eyes and hair somewhere on the spectrum of blond to brown or red hair with brown, hazel or green eyes. You must inherit two sets of genetic information for both your hair color and your eye color to have these less-common characteristics.

Redheads produce more vitamin D

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Everyone, including non-redheads, is welcome to attend the free, weekend-long festival. The only activity that is exclusively for natural redheads is the big group photoshoot, which happens on the last day of the event. In 2020, researchers at Charles University and the Institute of Endocrinology in Prague, Czech Republic, found that redheads are more efficient at synthesizing vitamin D.

Blue-eyed people are less likely to have vitiligo

Somewhere along the course of evolution, different eye colors emerged due to genetic mutations. Since then, these mutations have been passed down through generations. A research paper in the Journal of Human Genetics provides evidence that close to 16 genes may be responsible for eye color, and the way these interact with each other determine the specific shade of color. However, the two main genes involved in this process are the OCA2 and the HERC2 genes located on chromosome 15. The OCA2 gene is responsible for production of melanin, a molecule that imparts color.

Red Hair And Blue Eyes Is Rare

In fact, it’s the second most common in the United States after brown eyes. According to the American Academy of Ophthalmology, about 27% of Americans have blue eyes, while 45% have brown eyes. Across the world, 8% to 10% of people have blue eyes, which is still second place to brown eyes, which 70% to 80% of all individuals have. While light hair colors like shades of blond come to mind first when thinking of blue eyes, Megan Fox demonstrates how flatting a deep espresso brown is. The myth that blue eyes are a result of incest likely stems from amisunderstanding of genetics.

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However, if those genes are not activated, the error remains uncorrected, and the fetus is born with a cleft chin. "There are a number of ways rare traits can be lost from a population," says Professor Elgar. Brown freckles can develop in your iris over time, usually due to sun exposure.

If these mutations occur in the coding regions of the genes, they are further classified based on the type of effect seen in the resultant molecule. It is the condition where eyelids show presence of a double row of eyelashes. Hair follicles replace the oil glands present on the waterline along the eyelids. This occurs due to a mutation in the FOXC2 gene, which is responsible for most of the tissue development during embryogenesis. Extensive mutations in this gene may cause lymphedema and failure of the lymphatic system. Professor Elgar notes that MCR1 is also 'quantitative trait' which means that depending on which version of the mutation a person carries, there is variation in the appearance of those who carry the gene.

"The mutations occurred tens of thousands of years ago, and have now become established as different versions or variants of the genes that help determine our skin and eye colour. “In summer, most Victorians need just a few minutes of sun exposure mid-morning or mid-afternoon for vitamin D levels. The body only absorbs a limited amount of vitamin D at a time, so spending extra time in the sun won’t increase vitamin D levels, but will increase your risk of skin cancer. So all of us need to protect our skin when we’re outdoors during sun protection times (when the UV level is 3 or higher). “The mutations occurred tens of thousands of years ago, and have now become established as different versions or variants of the genes that help determine our skin and eye colour. Redheads have fewer strands of hair on their heads than those with more common hair colors but the hair is thicker to make up for the difference in volume.

The two main types of melaninresponsible for eye color are eumelanin, which is brown or black, andpheomelanin, which is red or yellow. The combination of these pigmentsdetermines the different shades of eye color, ranging from brown to green toblue. So while blondes may have more fun, redheads are halfway to having the rarest hair color and eye color combination. Given that red hair is the default hair color (via Human Mutation), it will be interesting to see what future research reveals about the rarity of red hair and blue eyes — and what other combinations are even rarer. As a result, red hair tends to become lighter in color as people age.

Since the gene is mutated, the melanin produced exhibits a shade of red. Around 17 per cent of people have blue eyes, and when combined with 1-2 per cent having red hair, the odds of having both traits are around 0.17 per cent. As I said earlier, your chances for a child with blue or green eyes are around 50%. These chances are based on an eye color model where two genes determine eye color. Scientists believe, therefore, that everyone with blue eyes today can be traced back to one ancestor who had that genetic mutation. There is limited scientific research regarding being a redhead and a "lefty," but it seems to be common.

These pigments are coded for by different forms of the MC1R gene. The expression of this gene, however, is controlled by various other genes. The melanocortin 1 receptor (MC1R) gene in its normal form produces pheomelanin and converts it into eumelanin. In the event of mutation, the amount of pheomelanin builds up, and is not converted into eumelanin. While redheads may be at higher risk of skin cancer than other Australians, we are all susceptible to the disease. So all of us need to protect our skin when we're outdoors during sun protection times (when the UV level is 3 or higher).

Dark gray eyes have a bit more melanin in the front layer than pale gray eyes. Researchers predict that because the MC1R mutation results in higher levels of the reddish pigment phaeomelanin, this results in greater susceptibility to UV damage to DNA. Studies also show that surgeons need to use 19 per cent more anaesthetic on redheaded women than brown-haired women to sedate them. The flow-on effect of the mutation is not only pale skin, but red hair and often freckles too.

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